15-year survival of patients on antiretroviral drugs similar to general population

In a recently published study by Hamish McManus and colleagues reported on long term survival and mortality in HIV-positive patients receiving anti-retroviral medication (cART )in the Australian HIV Observational Database (AHOD) and compared them to the general population.

They showed that observed mortality remained fairly constant by duration of cART and was modelled accurately by accepted prognostic factors.These rates did not vary much by duration of treatment.

Unlike previous studies which had shown an increase in mortality in HIV patients compared to matched non-infected populations changes in mortality with age were similar to those in the Australian general population. The increased mortality is more pronounced in females but is observed in both sexes and is unrelated to known risk factors such as smoking, hypertension, blood fat abnormalities, or obesity and is thought to relate to long term effects of anti-reroviral therapies currently in use.

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